Wenjian Zhou
( The barley Center of
Zhejiang Academy of Agriculture Science,
No.198 Shiqiao Road, Hangzhou, Zhejiang province, China, P C: 310021 )[1]
It is well known, life is
composed of protein, and protein is composed of amino acid, amino acid is
controled by DNA.
Then, if we can make
clear about the rule of sequence in DNA, secret of life will be discovered.
At present, two western
biologists Warson and Cfick have gotten a macroscopical qualitative rule about
DNA, -- the famous “ Double helix frame “. Base on it, almost all of
biologists of different countries pay theirs attention into quantitative
studying on pieces of DNA and studying genes quantitatively in the field of
molecular biology. And the main study technique is analyzing sequence of genes
through modern instrument-code of DNA. However, what can we gain from this scrap
data of the research? How can we apply it into practice? Can we understand the
essence of rule in DNA in a whole through it?
If we consider this
question resorting to the eastern philosophy wisdom of whole eyesight,
especially is the way from“ YiJing ”—a book discovering the change of
nature, we will get a surprise result, that is, DNA codes are a group of very
exact and regular binary numbers. However, I don’t know how to use this
discover till now. The further problem is, what control the code of DNA, and
make it compose by binary rule? It is a kind of certain information, and
information is something “invisible“.
Key
word: protein, amino acid, DNA, binary.
A.
Foreword
One
time, when I was reading a book that is the best abstract about Chinese
philosophy thought and culture headstream named “ YiJing “, found by chance
that there is a few relation between its rule and DNA code, studied it
carefully, and found that the DNA is a group of data code which is formed by
binary rule.
It
is why I wrote such a article, maybe it is not fitting requests of technical
paper, but perhaps persons will get some elicitation from here and be benefit to
their professional work.
Let’s
have a simple review at some basic knowledge about DNA which was in middle
school biology text.
We
know, very important in cell is chromosome, it control the character and
propagating of cell. But chromosome just is the carrier, what work really in it
is DNA molecule, it is existing as a frame of “ Double Screw Frame”, which
list both side are phosphate molecule and to oxigenate ribose molecule, this is
the same to all DNA, the part which control information are the different order
of alkali-basis which hide in the middle. These four DNA-bases are adenine A
Guanine G cytosine C and thymine T, respectively, and the rule of that they make
a partnership is A to T and G to C, this is named “ Centraldogma “ the rule
of DNA-bases partnership and supplementing each other.
In fact, DNA-base is
carrier too, the “list order” of DNA-bases is the real descendiblity
information. And we know, “
order” itself is “ empty, nothing”. It is obvious that it is the very
“empty, nothing” information controls the tangible substance list and frame.
This also shows out the relation quiddity of image and number (
relation of “Xiang” and “Shu” saying in Chinese term ):
It is nothing itself, but it controls the image.
One side, DNA distribute
itself into two son-cells averagely by copy itself, so realize itself
descendiblity, on the other side, it control the character of life-form through
controlling protein composing, DNA controls protein composing by transferring
its information from karyon to cytoplasm through the course of re-record of RNA.
In messenger RNA, replace T with U to make partnership with A. in ribosome of
cytoplasm, take the RNA as a model , carry the dissociative amino acid onto
ribosome by transfer RNA , then list the amino-acid and compose it as protein
according to the bases list order of RNA, there are three RNA-bases transfer
make partnership with RNA, the other top load dissociative amino acid.
Above is referencing the knowledge of
descendiblity and aberrance of biology text of senior middle school. It wrote in
the end of this chapter, protein is composed by 20 sorts of amino acid which are
being common, thus here is a problem of that how four sorts DNA-bases to decide
twenty sorts of amino acid, people have made this problem clear elementarily
these years, that is, decide a amino acid by different list order of three
DNA-bases. Now people have checked out all the 20 sorts of amino acid code as
below table.
Code |
|
Alanine |
GCA,
GCG, GCC,
GCU, |
Arginine |
CGA,
CGG, CGC,
CGU, AGA,
AGG, |
Aspartic acid |
AAC,
AAU |
Asparagine |
GAC,
GAU |
Cystine |
UGC,
UGU |
Glutamic
acid |
GAA,
GAG |
Glutamine |
CAA,
CAG |
Glycine |
GGC,
GGU, GGA,
GGG |
Histidine |
CAC,
CAU |
Isoleucine |
AUC,
AUU, AUA |
Leucine |
CUC,
CUU, CUA,
CUG, UUA,
UUG |
Lysine |
AAA,
AAG |
Methionine |
AUG |
Phenylalanine |
UUU,
UUC |
Proline |
CCA,
CCG, CCC,
CCU |
Serine |
UCA,
UCG, UCC,
UCU, AGU,
AGC |
Threonine |
ACA,
ACG, ACC,
ACU |
Tryptophane |
UGG |
Tyrosine |
UAC,
UAU |
Valine |
GUA,
GUG, GUC,
GUU |
Let’s look at this
table, there are two obvious shortcoming on this table:
1. the codes of that
decide amino acid are disorder and irregular, there is
1 , 2, 3, 4, and 6 .
2. the total number of codes in this
table are 61, and according to mathematical calculate, the total feasibilities
of that fetch 3 from 4 DNA-bases amino acids to make permutation and combination
should be 64 sorts, it is possible here lost three codes. So this table is not
orderly and complete in fact, according conclusion , there should be 64 sorts
codes total.
B.
Ratiocination on binary
Say simply, there are two
sorts of nucleotide : purin and pyrimidine, among them, purin are divided as
adenine A and Guanine G; pyrimidine are divided as cytosine C and thymine T.
We may suppose: adenine A
= 1, Guanine G = 2, cytosine C = 3, thymine T = 4 .
If we express them by
binary number as below: A = 00, G = 01, C = 10, T = 11.
Then we replace the
corresponding nucleotide name of the two tables into binary number.
20
amino acid and their codes
The
old codes express by binary number |
|
Alanine |
011000,
011001, 011010,
011011, |
Arginine |
100100,
100101, 100110,
100111, 000100,
000101, |
Aspartic acid |
000010,
000011 |
Asparagine |
010010,
010011 |
Cystine |
110110,
110111 |
Glutamic acid |
010000,
010001 |
Glutamine |
100000,
100001 |
Glycine |
010110,
010111, 010100,
010101 |
Histidine |
100010,
100011 |
Isoleucine |
001110,
001111, 001100 |
Leucine |
101110,
101111, 101100,
101101, 111100,
111101 |
Lysine |
000000,
000001 |
Methionine |
001101 |
Phenylalanine |
111111,
111110 |
Proline |
101000,
101001, 101010,
101011 |
Serine |
111000,
111001, 111010,
111011, 000111,
000110 |
Threonine |
001000,
001001, 001010,
001011 |
Tryptophane |
110101 |
Tyrosine |
110010,
110011 |
Valine |
011100,
011101, 011110,
011111 |
16
sorts amino acid and their codes ( reformed )
Reformed
codes express by binary bumber |
|
TL-ine |
000000,
000001, 000010,
000011, |
TG-ine |
000100,
000101, 000110,
000111 |
GZ-ine |
001000,
001001, 001010,
001011 |
Tyrosine |
001100,
001101, 001110,
001111 |
JJ-ine |
010000,
010001, 010010,
010011 |
Glycin |
010100,
010101, 010110,
010111 |
Arginine |
011000,
011001, 011010,
011011 |
BS-ine |
011100,
011101, 011110,
011111 |
Threonine |
100000,
100001, 100010,
100011 |
Alanine |
100100,
100101, 100110,
100111 |
Proline |
101000,
101001, 101010,
101011 |
Serine |
101100,
101101, 101110,
101111 |
YJ-ine |
110000,
110001, 110010,
110011 |
Valine |
110100,
110101, 110110,
110111 |
Leucine |
111000,
111001, 111010,
111011 |
Phenylalanine |
111100,
111101, 111110,
111111 |
Then
list the total codes according to its order, and express them by natural number
respectively.
Reformed
codes express by natural number |
|
TL-ine |
1,
2, 3,
4 |
TG-ine |
5,
6, 7,
8 |
GZ-ine |
9,
10, 11,
12, |
Tyrosine |
13,
14, 15,
16, |
JJ-ine |
17,
18, 19,
20, |
Glycin |
21,
22, 23,
24, |
Arginine |
25,
26, 27,
28, |
BS-ine |
29,
30, 31,
32, |
Threonine |
33,
34, 35,
36, |
Alanine |
37,
38, 39,
40, |
Proline |
41,
42, 43,
44, |
Serine |
45,
46, 47,
48, |
YJ-ine |
49,
50, 51,
52, |
Valine |
53,
54, 55,
56, |
Leucine |
57,
58, 59,
60, |
Phenylalanine |
61,
62, 63,
64, |
Then
list the total codes according to its order, and express them by nucleotide
name, respectively.
Reformed
codes express by nucleotide name |
|
TL-ine |
AAA,
AAG, AAC,
AAU |
TG-ine |
AGA,
AGG, AGC,
AGU |
GZ-ine |
ACA,
ACG, ACC,
ACU |
Tyrosine |
AUA,
AUG, AUC,
AUU |
JJ-ine |
GAA,
GAG, GAC,
GAU |
Glycin |
GGA,
GGG, GGC,
GGU |
Arginine |
GCA,
GCG, GCC,
GCU |
BS-ine |
GUA,
GUG, GUC,
GUU |
Threonine |
CAA,
CAG, CAC,
CAU |
Alanine |
CGA,
CGG, CGC,
CGU |
Proline |
CCA,
CCG, CCC,
CCU |
Serine |
CUA,
CUG, CUC,
CUU |
YJ-ine |
UAA,
UAG, UAC,
UAU |
Valine |
UGA,
UGG, UGC,
UGU |
Leucine |
UCA,
UCG, UCC,
UCU |
Phenylalanine |
UUA,
UUG, UUC,
UUU |
That
is to say, the 16 sorts amino acid what expressed by 64 nucleotides just are a
list of natural number of 6 binary number which are composed by 4 DNA-bases, and
it has 64 numbers from 1 to 64 total. Namely 2 6 = 64 , this just is
all of the secret of biology, and the secret of whole nature or world !
Let’s turn back to have a look at the old table, then express it as
natural number , to see what secret is there:
Old
codes express by natural number |
|
Alanine |
25,
26, 27,
28, |
Arginine |
37,
38, 39,
40, 5,
6, |
Aspartic acid |
3,
4 |
Asparagine |
19,
20 |
Cystine |
55,
56 |
Glutamic acid |
17,
18 |
Glutamine |
33,
34 |
Glycine |
23,
24, 21,
22 |
Histidine |
35,
36 |
Isoleucine |
15,
16, 13 |
Leucine |
47,
48, 45,
46, 61,
62 |
Lysine |
1,
2 |
Methionine |
14 |
Phenylalanine |
64,
63 |
Proline |
41,
42, 43,
44 |
Serine |
57,
58, 59,
60, 8,
7 |
Threonine |
9,
10, 11,
12 |
Tryptophane |
54 |
Tyrosine |
51,
52 |
Valine |
29,
30, 31,
32 |
We
may see from above table, so-called amino acid codes, it is breaking the order
of the 64 numbers from 1 —
64 then pick a piece of them put down casually.
Then it is who broken it
in the end? Only can be the God .
But we are wrong again, the God hasn’t broken it himself , it is mankind
ourselves who broken it when we study it, because the course of experimentation
always are single and disorder. In fact, the God distribute every life including
any life from virus to us person a only number for recognizing, just like ours
citizen ID card number, just this ID number which the God give us is more long,
but its basic unit is more simple in fact ! There
just are 0 and 1 two numbers, and mankind citizen ID is 15 digital number
composed by 0 to 9 these ten numbers. If the calculation speed of computer is
fast enough , suppose we will have a kind of quanta computer, then whether we
can find out all ID of life in the world? But I think the ID number of life is
only, it is no use in fact. The most important is to sum up the rule of how the
God compile these code, and the same part in this long coding, and in fact, this
rule is showed clearly: all lift have their mutual forebear, and the ultimate of
this mutual forbear is very simple really, that is 0 and 1 these two number, and
it can be sum up to 0, even the 0 is not exist too, this is the mutual thought
of Chinese thinker, it perhaps will disappointed those west scientists who are
ambitious !
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