The  binary  rule  of  DNA

Wenjian  Zhou

( The barley Center of Zhejiang Academy of Agriculture Science,

No.198 Shiqiao Road, Hangzhou,  Zhejiang province, China,  P C: 310021 )[1]

Abstract

It is well known, life is composed of protein, and protein is composed of amino acid, amino acid is controled by DNA.

 

Then, if we can make clear about the rule of sequence in DNA, secret of life will be discovered.

 

At present, two western biologists Warson and Cfick have gotten a macroscopical qualitative rule about DNA, -- the famous “ Double helix frame “. Base on it, almost all of biologists of different countries pay theirs attention into quantitative studying on pieces of DNA and studying genes quantitatively in the field of molecular biology. And the main study technique is analyzing sequence of genes through modern instrument-code of DNA. However, what can we gain from this scrap data of the research? How can we apply it into practice? Can we understand the essence of rule in DNA in a whole through it?

If we consider this question resorting to the eastern philosophy wisdom of whole eyesight, especially is the way from“ YiJing ”—a book discovering the change of nature, we will get a surprise result, that is, DNA codes are a group of very exact and regular binary numbers. However, I don’t know how to use this discover till now. The further problem is, what control the code of DNA, and make it compose by binary rule? It is a kind of certain information, and information is something “invisible“.

 

Key word: protein, amino acid, DNA, binary.

A. Foreword

One time, when I was reading a book that is the best abstract about Chinese philosophy thought and culture headstream named “ YiJing “, found by chance that there is a few relation between its rule and DNA code, studied it carefully, and found that the DNA is a group of data code which is formed by binary rule.

It is why I wrote such a article, maybe it is not fitting requests of technical paper, but perhaps persons will get some elicitation from here and be benefit to their professional work.

Let’s have a simple review at some basic knowledge about DNA which was in middle school biology text.

We know, very important in cell is chromosome, it control the character and propagating of cell. But chromosome just is the carrier, what work really in it is DNA molecule, it is existing as a frame of “ Double Screw Frame”, which list both side are phosphate molecule and to oxigenate ribose molecule, this is the same to all DNA, the part which control information are the different order of alkali-basis which hide in the middle. These four DNA-bases are adenine A Guanine G cytosine C and thymine T, respectively, and the rule of that they make a partnership is A to T and G to C, this is named “ Centraldogma “ the rule of DNA-bases partnership and supplementing each other.

In fact, DNA-base is carrier too, the “list order” of DNA-bases is the real descendiblity information.  And we know, “ order” itself is “ empty, nothing”. It is obvious that it is the very “empty, nothing” information controls the tangible substance list and frame. This also shows out the relation quiddity of image and number relation of “Xiang” and “Shu” saying in Chinese term : It is nothing itself, but it controls the image.

One side, DNA distribute itself into two son-cells averagely by copy itself, so realize itself descendiblity, on the other side, it control the character of life-form through controlling protein composing, DNA controls protein composing by transferring its information from karyon to cytoplasm through the course of re-record of RNA. In messenger RNA, replace T with U to make partnership with A. in ribosome of cytoplasm, take the RNA as a model , carry the dissociative amino acid onto ribosome by transfer RNA , then list the amino-acid and compose it as protein according to the bases list order of RNA, there are three RNA-bases transfer make partnership with RNA, the other top load dissociative amino acid.

Above is referencing the knowledge of descendiblity and aberrance of biology text of senior middle school. It wrote in the end of this chapter, protein is composed by 20 sorts of amino acid which are being common, thus here is a problem of that how four sorts DNA-bases to decide twenty sorts of amino acid, people have made this problem clear elementarily these years, that is, decide a amino acid by different list order of three DNA-bases. Now people have checked out all the 20 sorts of amino acid code as below table.

 

 

 

 

 

 

20  Sorts of amino acid and their codes

Amino acid

Code

Alanine

GCA,  GCG,  GCC,  GCU, 

Arginine

CGA,  CGG,  CGC,  CGU,  AGA,  AGG,

Aspartic acid

AAC,  AAU

Asparagine

GAC,  GAU

Cystine

UGC,  UGU

Glutamic acid

GAA,  GAG

Glutamine

CAA,  CAG

Glycine

GGC,  GGU,  GGA,  GGG

Histidine

CAC,  CAU

Isoleucine

AUC,  AUU,  AUA

Leucine

CUC,  CUU,  CUA,  CUG,  UUA,  UUG

Lysine

AAA,  AAG

Methionine

AUG

Phenylalanine

UUU,  UUC

Proline

CCA,  CCG,  CCC,  CCU

Serine

UCA,  UCG,  UCC,  UCU,  AGU,  AGC

Threonine

ACA,  ACG,  ACC,  ACU

Tryptophane

UGG

Tyrosine

UAC,  UAU

Valine

GUA,  GUG,  GUC,  GUU

Let’s look at this table, there are two obvious shortcoming on this table:

1. the codes of that decide amino acid are disorder and irregular, there is  1 , 2, 3, 4, and 6 .

2. the total number of codes in this table are 61, and according to mathematical calculate, the total feasibilities of that fetch 3 from 4 DNA-bases amino acids to make permutation and combination should be 64 sorts, it is possible here lost three codes. So this table is not orderly and complete in fact, according conclusion , there should be 64 sorts codes total.

B.  Ratiocination on binary

Say simply, there are two sorts of nucleotide : purin and pyrimidine, among them, purin are divided as adenine A and Guanine G; pyrimidine are divided as cytosine C and thymine T.

We may suppose: adenine A = 1, Guanine G = 2, cytosine C = 3, thymine T = 4 .

If we express them by binary number as below: A = 00, G = 01, C = 10, T = 11.

Then we replace the corresponding nucleotide name of the two tables into binary number.

 

20 amino acid and their codes

Amino acid

The old codes express by binary number

Alanine

011000,  011001,  011010,  011011, 

Arginine

100100,  100101,  100110,  100111,  000100,  000101,

Aspartic acid

000010,  000011

Asparagine

010010,  010011

Cystine

110110,  110111

Glutamic acid

010000,  010001

Glutamine

100000,  100001

Glycine

010110,  010111,  010100,  010101

Histidine

100010,  100011

Isoleucine

001110,  001111,  001100

Leucine

101110,  101111,  101100,  101101,  111100,  111101

Lysine

000000,  000001

Methionine

001101

Phenylalanine

111111,  111110

Proline

101000,  101001,  101010,  101011

Serine

111000,  111001,  111010,  111011,  000111,  000110

Threonine

001000,  001001,  001010,  001011

Tryptophane

110101

Tyrosine

110010,  110011

Valine

011100,  011101,  011110,  011111

16 sorts amino acid and their codes ( reformed )

Amino acid

Reformed codes express by binary bumber

TL-ine

000000,  000001,  000010,  000011,

TG-ine

000100,  000101,  000110,  000111

GZ-ine

001000,  001001,  001010,  001011

Tyrosine

001100,  001101,  001110,  001111

JJ-ine

010000,  010001,  010010,  010011

Glycin

010100,  010101,  010110,  010111

Arginine

011000,  011001,  011010,  011011

BS-ine

011100,  011101,  011110,  011111

Threonine

100000,  100001,  100010,  100011

Alanine

100100,  100101,  100110,  100111

Proline

101000,  101001,  101010,  101011

Serine

101100,  101101,  101110,  101111

YJ-ine

110000,  110001,  110010,  110011

Valine

110100,  110101,  110110,  110111

Leucine

111000,  111001,  111010,  111011

Phenylalanine

111100,  111101,  111110,  111111

Then list the total codes according to its order, and express them by natural number respectively.

 

Amino acid

Reformed codes express by natural number

TL-ine

1,    2,   3,   4

TG-ine

5,    6,   7,   8

GZ-ine

9,   10,  11,  12,

Tyrosine

13,  14,  15,  16,

JJ-ine

17,  18,  19,  20,

Glycin

21,  22,  23,  24,

Arginine

25,  26,  27,  28,

BS-ine

29,  30,  31,  32,

Threonine

33,  34,  35,  36,

Alanine

37,  38,  39,  40,

Proline

41,  42,  43,  44,

Serine

45,  46,  47,  48,

YJ-ine

49,  50,  51,  52,

Valine

53,  54,  55,  56,

Leucine

57,  58,  59,  60,

Phenylalanine

61,  62,  63,  64,

 

Then list the total codes according to its order, and express them by nucleotide name, respectively.

 

Amino acid

Reformed codes express by nucleotide name

TL-ine

AAA,  AAG,  AAC,  AAU

TG-ine

AGA,  AGG,  AGC,  AGU

GZ-ine

ACA,  ACG,  ACC,  ACU

Tyrosine

AUA,  AUG,  AUC,  AUU

JJ-ine

GAA,  GAG,  GAC,  GAU

Glycin

GGA,  GGG,  GGC,  GGU

Arginine

GCA,  GCG,  GCC,  GCU

BS-ine

GUA,  GUG,  GUC,  GUU

Threonine

CAA,  CAG,  CAC,  CAU

Alanine

CGA,  CGG,  CGC,  CGU

Proline

CCA,  CCG,  CCC,  CCU

Serine

CUA,  CUG,  CUC,  CUU

YJ-ine

UAA,  UAG,  UAC,  UAU

Valine

UGA,  UGG,  UGC,  UGU

Leucine

UCA,  UCG,  UCC,  UCU

Phenylalanine

UUA,  UUG,  UUC,  UUU

That is to say, the 16 sorts amino acid what expressed by 64 nucleotides just are a list of natural number of 6 binary number which are composed by 4 DNA-bases, and it has 64 numbers from 1 to 64 total. Namely 2 6 = 64 , this just is all of the secret of biology, and the secret of whole nature or world !  Let’s turn back to have a look at the old table, then express it as natural number , to see what secret is there:

Amino acid

Old codes express by natural number

Alanine

25,  26,  27,  28, 

Arginine

37,  38,  39,  40,  5,  6,

Aspartic acid

3,  4

Asparagine

19,  20

Cystine

55,  56

Glutamic acid

17,  18

Glutamine

33,  34

Glycine

23,  24,  21,  22

Histidine

35,  36

Isoleucine

15,  16,  13

Leucine

47,  48,  45,  46,  61,  62

Lysine

1,  2

Methionine

14

Phenylalanine

64,  63

Proline

41,  42,  43,  44

Serine

57,  58,  59,  60,  8,  7

Threonine

9,  10,  11,  12

Tryptophane

54

Tyrosine

51,  52

Valine

29,  30,  31,  32

We may see from above table, so-called amino acid codes, it is breaking the order of the 64 numbers from 1 64 then pick a piece of them put down casually.

Then it is who broken it in the end?  Only can be the God . But we are wrong again, the God hasn’t broken it himself , it is mankind ourselves who broken it when we study it, because the course of experimentation always are single and disorder. In fact, the God distribute every life including any life from virus to us person a only number for recognizing, just like ours citizen ID card number, just this ID number which the God give us is more long, but its basic unit is more simple in fact !  There just are 0 and 1 two numbers, and mankind citizen ID is 15 digital number composed by 0 to 9 these ten numbers. If the calculation speed of computer is fast enough , suppose we will have a kind of quanta computer, then whether we can find out all ID of life in the world? But I think the ID number of life is only, it is no use in fact. The most important is to sum up the rule of how the God compile these code, and the same part in this long coding, and in fact, this rule is showed clearly: all lift have their mutual forebear, and the ultimate of this mutual forbear is very simple really, that is 0 and 1 these two number, and it can be sum up to 0, even the 0 is not exist too, this is the mutual thought of Chinese thinker, it perhaps will disappointed those west scientists who are ambitious !



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